Search results for "Mucin permeation"

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Polymeric drug delivery micelle-like nanocarriers for pulmonary administration of beclomethasone dipropionate

2017

In this paper, the potential of novel polymeric micelles as drug delivery systems for Beclomethasone Dipropionate (BDP) administration into the lung is investigated. These nanostructures are obtained starting from α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA), which was subsequently functionalized with O-(2-aminoethyl)-O’-methylpolyethylenglycole (PEG2000), ethylenediamine (EDA) and lipoic acid (LA), obtaining PHEA-PEG2000-EDA-LA graft copolymer. Empty and drug-loaded micelles possess adequate chemical-physical characteristics for pulmonary administration such as spherical shape, slightly positive surface charge and mean size of about 200 nm. Besides, BDP-loaded micelles, obtained …

Surface PropertieAnti-Inflammatory AgentsBiocompatible MaterialsMucin permeation02 engineering and technologyPharmacology030226 pharmacology & pharmacyMicelleAntioxidantsDrug Delivery Systems0302 clinical medicineNanoparticleColloid and Surface ChemistryCopolymerDrug CarrierLungMicellesmedia_commonCell uptakeBiocompatible MaterialDrug CarriersLipoic acidThioctic AcidChemistryBeclomethasoneSurfaces and InterfacesGeneral Medicinerespiratory systemEthylenediamines021001 nanoscience & nanotechnologyPolyaspartamideAnti-Inflammatory AgentDrug deliveryPeptideAntioxidant0210 nano-technologyDrug carrierSurfaces and InterfaceHumanBiotechnologyDrugBiocompatibilitySurface PropertiesCell Survivalmedia_common.quotation_subjectEthylenediamineBronchi03 medical and health sciencesMicroscopy Electron TransmissionPolymeric micelleHumansSurface chargeParticle SizePhysical and Theoretical ChemistryEpithelial CellEthanolEpithelial CellsMicroscopy FluorescenceSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoNanoparticlesNanocarriersPeptidesDrug Delivery SystemNuclear chemistrySustained releaseMicelle
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